Alpha-GPC Chemical Information:
- CAS Number: 28319-77-9
- Appearance: Powder
- Chemical Names: Alpha-glycerylphosphorylcholine, L-alpha-glycerophosphocholin, glycerophosphocholine, L-alpha-glyceryl-phosphorylcholine, Choline Alphoscerate
- Molecular Formula: C8H20NO6P
- Molecular Weight: 257.221 g/mol
Alpha-GPC Other Names:
- Also Known As: L-alpha-glycerophosphocholin, L-alpha-glyceryl-phosphorylcholine, Choline Alphoscerate, Alfa-GPC, Alpha Glycerol Phosphoryl Choline, Alpha-Glyceryl Phosphoryl Choline, Alpha-Glyceryl Phosphatidylcholine, Alpha-glycerylphosphorylcholine, Choline alphoscerate, Glycerophosphorylcholine, Glycérophosphorylcholine, GPC, GroPCho, L-A-Glyceryl Phosphorylcholine
Alpha-GPC Chemical Structure:
Alpha-glycerophosphocholine (Alpha-GPC or α-GPC) is a cholinergic compound that is used for its cognitive-promoting properties, and to enhance power output in athletes. It appears to also support cellular membranes, and may aid in preventing cognitive decline.
Alpha-GPC is mostly marketed due to it conferring dietary choline to the body following oral ingestion, and being the most efficient choline prodrug at doing so (able to influence both systemic and brain concentrations of choline). Due to the provision of the other half of the alpha-GPC molecule (glycerophosphate), alpha-GPC also appears to support the structure of cellular membranes, which is not a common mechanism attributed to choline prodrugs (only CDP-choline is associated with lipid membranes in this sense).
Oral supplementation of alpha-GPC is of interest for nootropic purposes, as it appears to have cognitive-enhancing properties (no human evidence exists to support this in otherwise-healthy youth, but it does have support in rodents) and attenuate the rate of cognitive decline in the elderly. In regards to reducing the rate of cognitive decline, alpha-GPC at high doses (1,200 mg) does appear to be somewhat effective in mild to moderate Alzheimer’s disease and works nicely with the standard therapy (acetylcholinesterase inhibitors).
Athletes are at times interested in alpha-GPC due to its ability to enhance growth hormone production (of which only acute spikes have been reported so far, so it may fall to the same problems that Arginine has on growth hormone) and to enhance power output, which has a lone pilot study in support of 600 mg alpha-GPC prior to exercise. Although ergogenic properties of alpha-GPC cannot be ruled out and look promising, it requires more evidence.
Benefits of Alpha-GPC
Alpha GPC is one of the world’s best choline sources. It’s been linked with a number of powerful cognitive benefits:
1. Boost Your Memory: Choline synthesis acetylcholine, which plays a critical role in memory formation and reduces the effects of degenerative memory disorders like Alzheimer’s and dementia. On individuals with healthy brains, Alpha-GPC can increase your learning ability, making it easier for your brain to store new information and recall that information at a later date.
2. Enhance Focus, Attention, And Clarity: Alpha-GPC is a popular study aid because it boosts memory while also increasing focus, attention, and clarity. Higher levels of acetylcholine streamline neurotransmission between brain cells, which leads to better overall focus.
3. Boost Energy: People who have low levels of acetylcholine often have problems with energy and fatigue. Taking Alpha GPC can boost mental and physical energy levels.
Improve Mood: Alpha-GPC is thought to affect dopamine systems in the brain. Dopamine is a powerful neurotransmitter which plays a critical role in regulating mood. Higher dopamine levels can reduce stress and treat depression.
How to Take Alpha-GPC
Taken by itself, a good starting dose is about 250 mg of 100% alpha-GPC. A standard dosage of alpha-GPC is 300-600 mg for powerful cognitive effects. lpha-GPC is water soluble but sometimes sold mixed with other substances that are not. It can be put it in capsules and washed down with a drink. It combines positively with all racetams and may improve their effectiveness, besides reducing or eliminating headaches.
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