Citicoline Chemical Information
- CAS Number:987-78-0
- Formula: C14H27N4O11P2
- Molar mass: 489.332 g/mol
Citicoline Other names:
- CDP Choline
- cytidine diphosphate-choline
- Cytidine 5′-diphosphocholine
- Cytidine Diphosphocholine
Citicoline Chemical Structure
Citicoline also known as cytidine diphosphate-choline (CDP-Choline) or cytidine 5′-diphosphocholine is a psychostimulant/nootropic. CDP-choline (citicholine) is a nootropic compound that converts to both Choline and cytidine upon ingestion, the latter of which converts into Uridine in the body. It appears to confer cognitive-promoting properties as a prodrug for these two compounds.
This supplement is catered towards preventing or treating memory impairments associated with aging due to the fact that both of the molecules it confers are neuroprotective and potentially enhance learning. While it appears to be more effective than phosphatidylcholine (PC) at this role, in part due to also increasing PC synthesis in the brain, its potency is somewhat comparable to that of Alpha-GPC.
CDP-choline has some other potential uses in relation to cognition. It is commonly used as a memory enhancer in youth, but despite some rodent studies suggesting that this is possible with oral CDP-choline, there are no human studies in youth at this point in time. One study has noted an increase in attention with low dose CDP-choline (which needs to be replicated), and CDP-choline may have roles as an anti-addictive compound against both cocaine and (preliminary evidence suggests) food as well.
Citicoline Recommended dosage
Standard dosing of CDP-choline is to take 500-2,000 mg in two divided doses (of 250-1,000 mg) usually separated by 8-12 hours, although a single daily dose is also sometimes used.